Description

n-Acetyl-D-Glucosamine-13C6 is a stable isotope-labeled analog of N-acetylglucosamine, where all six carbon atoms are the carbon-13 isotope. This compound is essential as an internal standard for the precise quantification and metabolic pathway tracing of N-acetylglucosamine in advanced analytical research. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers engaged in metabolomics, biomarker discovery, and pharmacokinetic studies.

Application

• Quantitative Mass Spectrometry (MS) & LC-MS/MS: Serves as a critical internal standard for the accurate and sensitive measurement of endogenous N-acetylglucosamine levels in complex biological matrices like serum, plasma, and tissue homogenates.
• Metabolic Flux Analysis (MFA): Used as a tracer to study the dynamics and rates of metabolic pathways involving hexosamine biosynthesis and glycosylation processes in cell culture and in vivo models.
• Biomarker Research & Validation: Enables the development of robust, isotope-dilution mass spectrometry assays for potential biomarkers related to osteoarthritis, inflammatory diseases, and other conditions where glycosaminoglycan metabolism is altered.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates the study of the absorption, distribution, metabolism, and excretion (ADME) of therapeutic compounds targeting glycosylation pathways.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Acts as a 13C-enriched probe for structural and dynamic studies of carbohydrate-protein interactions and enzymatic mechanisms.
• Quality Control in Biologics Manufacturing: Supports analytical methods for monitoring glycosylation patterns of therapeutic proteins, such as monoclonal antibodies, ensuring product consistency and efficacy.

Basic Information

Item	Details
Product Name	n-Acetyl-D-Glucosamine-13C6
CAS No.	1194446-34-8
Molecular Formula	C813C6H15NO6
Molecular Weight	~225.18 (for 13C6 labeled form)
Synonyms	N-Acetyl-13C6-glucosamine; 2-Acetamido-2-deoxy-13C6-D-glucopyranose; D-Glucosamine-13C6, N-acetyl-; N-Acetyl-D-glucosamine-13C6; 13C6-NAG; (3R,4R,5S,6R)-5-Acetamido-6-(hydroxymethyl)-2,3,4,5,6-pentakis(13C)oxane-2,3,4-triol; Acetylglucosamine-13C6; GlcNAc-13C6
EINECS	Contact for details

Quality Control

Our n-Acetyl-D-Glucosamine-13C6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity by HPLC, and confirmatory spectroscopic data. We adhere to cGMP principles for consistent production and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.