Description

1-Pyrrolidinecarboxylic Acid, 4,4-Difluoro-2-Formyl-, 1,1-Dimethylethyl Ester, (2S)- is a high-purity, chiral fluorinated pyrrolidine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which incorporates both a formyl group and fluorine atoms, making it a versatile building block for constructing complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals where stereochemistry and fluorination are key design elements.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in protease inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection agents, leveraging fluorine's ability to enhance metabolic stability and bioavailability.
• Organofluorine Chemistry Research: Serves as a valuable substrate for studying new fluorination methodologies and the effects of fluorine substitution on molecular properties.
• Peptidomimetic Development: The pyrrolidine core and formyl group make it an ideal precursor for designing and synthesizing peptidomimetics and conformationally constrained peptides.
• Ligand and Catalyst Preparation: Can be utilized to synthesize novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Fine Chemical Production: Employed in the multi-step synthesis of specialized, high-value fine chemicals and custom molecules for various industrial research applications.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 4,4-Difluoro-2-Formyl-, 1,1-Dimethylethyl Ester, (2S)-
CAS No.	1194032-45-5
Molecular Formula	C10H15F2NO3
Molecular Weight	235.23 g/mol
Synonyms	(2S)-tert-Butyl 4,4-difluoro-2-formylpyrrolidine-1-carboxylate; (S)-tert-Butyl 4,4-difluoro-2-formyl-1-pyrrolidinecarboxylate; 1-Boc-4,4-difluoro-2-formyl-(S)-proline tert-butyl ester; (S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-formylpyrrolidine; Boc-4,4-difluoro-D-prolinal tert-butyl ester; (S)-Boc-4,4-difluoro-2-formylpyrrolidine; 4,4-Difluoro-2-formyl-(S)-proline tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Pyrrolidinecarboxylic Acid, 4,4-Difluoro-2-Formyl-, 1,1-Dimethylethyl Ester, (2S)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is fully characterized and undergoes rigorous analytical testing, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.