Description

1-Butanaminium, N,N,n-Tributyl-, (1R,2S,5R)-2-(Aminocarbonyl)-7-Oxo-1,6-Diazabicyclo[3.2.1]Oct-6-Yl Sulfate is a high-purity, non-natural amino acid derivative and a key pharmaceutical intermediate. This compound is of significant commercial importance due to its role in the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of advanced therapeutic agents, particularly those targeting infectious diseases.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex β-lactamase inhibitors and other advanced antibiotic candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new pharmacologically active molecules.
• Process Chemistry: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of API manufacturing processes.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) or other targeted drug delivery systems due to its reactive functional groups.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical production.

Basic Information

Product Name	1-Butanaminium, N,N,n-Tributyl-, (1R,2S,5R)-2-(Aminocarbonyl)-7-Oxo-1,6-Diazabicyclo[3.2.1]Oct-6-Yl Sulfate
CAS No.	1192651-80-1
Molecular Formula	C23H46N4O6S
Molecular Weight	506.70 g/mol
Synonyms	Tributyl(1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-ylammonium sulfate; (1R,2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-aminium tributylsulfate; Avibactam tributylammonium salt; AVI-tributylammonium sulfate; NXL-104 tributylammonium salt; Diazabicyclooctane β-lactamase inhibitor intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Every lot is subjected to comprehensive analytical characterization using HPLC, NMR, and mass spectrometry to confirm identity, purity, and impurity profile. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support our clients' regulatory filings with comprehensive stability and validation data packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.