Description

Psi-7976 CAS NO 1190308-01-0 is a high-purity nucleoside phosphoramidite prodrug intermediate, a critical building block in the synthesis of modified oligonucleotides. Its primary value lies in enabling the precise and efficient production of therapeutic nucleic acids, including antisense oligonucleotides and small interfering RNA (siRNA). This compound is essential for pharmaceutical R&D and manufacturing teams focused on developing next-generation genetic medicines and advanced molecular diagnostics.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Key precursor in the solid-phase synthesis of therapeutic oligonucleotides targeting genetic disorders, cancers, and viral infections.
• Antiviral Drug Development: Critical intermediate for the production of nucleotide analogs used in direct-acting antiviral therapies, particularly for hepatitis C virus (HCV).
• Research & Development: Used in academic and industrial labs for studying RNA interference (RNAi) mechanisms and developing novel gene-silencing agents.
• siRNA & Antisense Oligonucleotide Manufacturing: Serves as a phosphoramidite monomer in automated synthesizers to produce research-grade and GMP-grade oligonucleotides.
• Diagnostic Probe Synthesis: Employed in the creation of labeled nucleic acid probes for advanced diagnostic assays and genomic research tools.

Basic Information

Product Name	Psi-7976
CAS No.	1190308-01-0
Molecular Formula	C₂₂H₂₉FN₃O₈P
Molecular Weight	513.46 g/mol
Synonyms	GS-7976; Sofosbuvir impurity; PSI-7977 intermediate; 2'-Fluoro-2'-C-methyluridine phosphoramidite prodrug intermediate; 2'-Deoxy-2'-α-fluoro-2'-β-C-methyluridine-5'-(phenyl methoxy-L-alaninyl) phosphate; (2R,3R,4R,5R)-2-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-3-yl (2S)-2-[[(S)-(phenoxy)phosphoryl]amino]propanoate
EINECS	Contact for details

Quality Control

Our Psi-7976 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support development through commercial scale with materials that can meet the stringent requirements of ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.