Description

5-Fluorodihydropyrimidine-2,4-Dione-13C,15N2 is a stable isotope-labeled analog of 5-fluorouracil, a cornerstone chemotherapeutic agent. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability for pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring precise analytical measurements.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of 5-fluorouracil and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical trials.
• Metabolic Pathway Research: Used to elucidate and quantify the complex metabolic pathways of fluoropyrimidine drugs.
• Therapeutic Drug Monitoring (TDM): Facilitates the development and validation of robust assays for monitoring patient drug levels to optimize chemotherapy regimens and minimize toxicity.
• Forensic and Doping Control Analysis: Provides definitive identification and quantification in compliance-driven testing environments.
• Manufacturing Process Control: Can be utilized in quality control during the synthesis of 5-fluorouracil-based pharmaceuticals.

Basic Information

Product Name	5-Fluorodihydropyrimidine-2,4-Dione-13C,15N2
CAS No.	1189492-99-6
Molecular Formula	C313CH3FN215N2O2
Molecular Weight	134.06 g/mol (for labeled form)
Synonyms	5-Fluorouracil-13C,15N2; [13C,15N2]-5-Fluorouracil; 5-FU-13C,15N2; 5-Fluoro-1H,3H-pyrimidine-2,4-dione-13C,15N2; 5-Fluoro-2,4(1H,3H)-pyrimidinedione-13C,15N2; Isotopically Labeled 5-Fluorouracil; 13C,15N2-5-FU; 5-Fluorouracil (13C,15N2)
EINECS	Contact for details

Quality Control

Our stable isotope-labeled compounds are manufactured under strict quality systems to ensure the highest isotopic and chemical purity for demanding analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by MS and NMR). We adhere to relevant guidelines for the production of reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (MS)	Conforms
Identification (NMR)	Conforms
Isotopic Purity	≥ 98 atom % 13C; ≥ 98 atom % 15N
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.