Description

Lamivudine Monophosphate Ammonium Salt is a key pharmaceutical intermediate, specifically the monophosphate prodrug form of the potent antiviral agent Lamivudine. This compound is critical for enhancing the bioavailability and targeted delivery of the active pharmaceutical ingredient in advanced drug formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of nucleoside reverse transcriptase inhibitor (NRTI) therapies for the treatment of HIV and Hepatitis B.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial prodrug intermediate in the manufacturing of Lamivudine and its combination drug products.
• Antiviral Drug Development: Used in research and development of next-generation nucleoside analog therapies targeting viral replication.
• Pharmaceutical Formulations: Incorporated into specialized dosage forms designed for improved cellular uptake and pharmacokinetic profiles.
• Biochemical Research: Employed as a standard or reagent in virology and molecular pharmacology studies to investigate mechanisms of antiviral action.
• Preclinical & Clinical Trial Materials: Supplied as a high-purity building block for producing materials used in non-clinical and clinical studies.

Basic Information

Product Name	Lamivudine Monophosphate Ammonium Salt
CAS No.	1187058-40-7
Molecular Formula	C8H15N4O7P
Molecular Weight	310.20 g/mol
Synonyms	Lamivudine 5'-Monophosphate Ammonium Salt; 2',3'-Dideoxy-3'-thiacytidine Monophosphate Ammonium Salt; 3TC Monophosphate Ammonium Salt; (-)-2',3'-Dideoxy-3'-thiacytidine 5'-(dihydrogen phosphate) ammonium salt; BCH-189 Monophosphate Ammonium Salt; GR-109714X Monophosphate Ammonium Salt; Epivir Intermediate; Ammonium ((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl phosphate
EINECS	Contact for details

Quality Control

Our Lamivudine Monophosphate Ammonium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of residual solvents and impurities to meet exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.