Description

2'-(Dicyclohexylphosphino)-N,n-Dimethyl[1,1'-Biphenyl]-4-Amine CAS NO 1185899-00-6 is a specialized, high-value phosphine ligand widely used in transition metal catalysis. Its primary value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental to modern pharmaceutical and advanced material synthesis. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require robust and reliable catalysts for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand in Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions for constructing C-N and C-C bonds in active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in catalytic processes to create complex heterocyclic compounds found in modern herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic light-emitting diodes (OLEDs), conductive polymers, and other advanced organic electronic materials via metal-catalyzed coupling.
• Process Chemistry & Scale-up: Valued for its stability and effectiveness under process conditions, facilitating the transition from laboratory-scale discovery to commercial manufacturing.
• Academic & Industrial R&D: A critical tool for methodological development in synthetic organic chemistry and catalysis research.
• Fine Chemical Production: Enables the synthesis of specialty flavors, fragrances, and other high-value, structurally complex molecules.

Basic Information

Product Name	2'-(Dicyclohexylphosphino)-N,n-Dimethyl[1,1'-Biphenyl]-4-Amine
CAS No.	1185899-00-6
Molecular Formula	C26H36N1P1
Molecular Weight	393.55 g/mol
Synonyms	DavePhos; 2-(Dicyclohexylphosphino)-N,N-dimethylbiphenyl-4-amine; 2-(Dicyclohexylphosphino)-N,N-dimethyl-[1,1'-biphenyl]-4-amine; 2'-Biphenyldicyclohexylphosphine-N,N-dimethylamine; N,N-Dimethyl-4-biphenylyl-2-dicyclohexylphosphine; [1,1'-Biphenyl]-4-amine, 2'-(dicyclohexylphosphino)-N,N-dimethyl-; DavePhos Ligand
EINECS	Contact for details

Quality Control

Our 2'-(Dicyclohexylphosphino)-N,n-Dimethyl[1,1'-Biphenyl]-4-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR, HPLC, and elemental analysis to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to a quality management system designed to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and stored in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.