Description

1-Benzyl-4-[(5,6-Dimethoxy-1-Oxoindan-2-Ylidene)Methyl]Piperidine-13C3 is a stable isotope-labeled analog of a key pharmaceutical intermediate, where three carbon atoms are replaced with the carbon-13 isotope. This compound is essential for conducting advanced pharmacokinetic, metabolic, and bioanalytical studies with high precision and accuracy. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions involved in drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in quantitative bioanalysis using liquid chromatography-tandem mass spectrometry, ensuring accurate measurement of the unlabeled drug in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) profile of pharmaceutical compounds in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in the definitive identification and structural elucidation of drug metabolites by providing a mass spectrometric reference.
• Method Development and Validation: Essential for developing and validating highly sensitive and specific analytical methods compliant with GLP and FDA/EMA guidelines.
• Stable Isotope Dilution Assays: Employed in precise quantification techniques where the labeled analog compensates for matrix effects and instrument variability.

Basic Information

Product Name	1-Benzyl-4-[(5,6-Dimethoxy-1-Oxoindan-2-Ylidene)Methyl]Piperidine-13C3
CAS No.	1185239-87-5
Molecular Formula	C25H27NO3 (with three 13C atoms)
Molecular Weight	~402.5 g/mol (exact mass depends on isotopic enrichment)
Synonyms	1-Benzyl-4-[(5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]piperidine-13C3; 13C3-Labeled Donepezil Intermediate; 4-[(5,6-Dimethoxy-1-oxoindan-2-ylidene)methyl]-1-benzylpiperidine-13C3; Benzylpiperidine-13C3 derivative; Isotopically Labeled Indanone Piperidine; API Intermediate-13C3; Carbon-13 Labeled Pharmaceutical Reference Standard
EINECS	Contact for details

Quality Control

Every batch of 1-Benzyl-4-[(5,6-Dimethoxy-1-Oxoindan-2-Ylidene)Methyl]Piperidine-13C3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive characterization including NMR (1H, 13C) and mass spectrometry to confirm structure and isotopic enrichment. Certificates of Analysis (COA) are provided, detailing assay, purity, and specific tests relevant to its use as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C (at designated positions)
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.