Description

Nε,Nε,Nε-Trimethyllysine-D9 is a stable isotope-labeled derivative of trimethyllysine, where nine hydrogen atoms are replaced by deuterium. This high-purity labeled compound is essential for precise quantitative analysis in metabolic and proteomic research, serving as a critical internal standard. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) specializing in mass spectrometry-based biomarker discovery and metabolic pathway analysis.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of endogenous trimethyllysine and related metabolites.
• Metabolomics Research: Enables stable isotope dilution analysis (SIDA) to study lysine metabolism, methylation pathways, and carnitine biosynthesis in biological samples.
• Biomarker Discovery and Validation: Critical for developing and validating high-sensitivity assays for potential biomarkers related to cardiovascular, renal, and metabolic disorders.
• Pharmaceutical Development: Supports pharmacokinetic (PK) and pharmacodynamic (PD) studies in drug development programs targeting metabolic enzymes.
• Nutritional and Clinical Research: Facilitates the investigation of nutrient metabolism, including choline and betaine pathways, in human and animal studies.
• Proteomics and Histone Analysis: Employed in the study of protein methylation, particularly in the analysis of histone modifications and epigenetic regulation.

Basic Information

Item	Detail
Product Name	Nε,Nε,Nε-Trimethyllysine-D9
CAS No.	1182037-78-0
Molecular Formula	C9H10D9N2O2+ (typically as a salt, e.g., chloride or hydrochloride)
Molecular Weight	Contact for details
Synonyms	Trimethyllysine-d9; TML-d9; N6,N6,N6-Trimethyl-L-lysine-d9; L-Lysine, N6,N6,N6-trimethyl-, ion(1+), d9; (2S)-2-Amino-6-(trimethylammonio-d9)hexanoate; Deuterated Trimethyllysine; Stable Isotope Labeled Trimethyllysine; 2-Amino-6-(trimethyl-d9-ammonio)hexanoic acid
EINECS	Contact for details

Quality Control

Every batch of Nε,Nε,Nε-Trimethyllysine-D9 is manufactured and tested under a strict quality management system. We guarantee high chemical and isotopic purity through advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and specific tests are provided with each shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (Chemical Purity)
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.