Description

R-Elvitegravir CAS NO 1177256-05-1 is a high-purity, non-racemic stereoisomer of the HIV-1 integrase strand transfer inhibitor, Elvitegravir. This compound is a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and is essential for research and development in advanced antiviral therapies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on virology and drug discovery.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of the antiviral drug Elvitegravir and related analogs.
• Active Pharmaceutical Ingredient (API) Research: Used in R&D for developing and optimizing next-generation HIV-1 integrase inhibitors.
• Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in mechanistic studies to understand the inhibition of HIV-1 integrase and viral replication pathways.
• Process Chemistry & Scale-Up: Integral to process development and optimization for the commercial manufacturing of antiviral medications.

Basic Information

Product Name	R-Elvitegravir
CAS No.	1177256-05-1
Molecular Formula	C₂₃H₂₃ClFNO₅
Molecular Weight	447.88 g/mol
Synonyms	(4R,12aS)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid 2,4-difluorobenzyl ester; (R)-Elvitegravir; GS-9137 (R-isomer); JTK-303 (R-isomer); R-Enantiomer of Elvitegravir
EINECS	Contact for details

Quality Control

Our R-Elvitegravir is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.