Description

cis-Urocanic Acid-[13C3] is a stable isotope-labeled analog of urocanic acid, specifically enriched with carbon-13 at three positions. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is primarily required by research institutions, pharmaceutical developers, and CROs engaged in advanced metabolomic studies, photobiology research, and the development of precise bioanalytical methods for skin-related biomarkers.

Application

• Quantitative Mass Spectrometry (MS) & LC-MS/MS: Serves as a critical internal standard for the accurate quantification of endogenous urocanic acid in complex biological matrices like plasma, urine, and skin tissue.
• Metabolomics & Biomarker Research: Enables precise tracking and measurement of urocanic acid pathways in studies related to immune modulation, UV-induced skin responses, and histidine metabolism.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in stable isotope dilution assays to study the absorption, distribution, metabolism, and excretion of compounds affecting the urocanic acid pathway.
• Photobiology and Dermatological Research: Facilitates research into the cis/trans isomerization of urocanic acid and its role as a natural sunscreen and immunomodulator following UV exposure.
• Method Development & Validation: Provides a definitive reference for developing, optimizing, and validating highly sensitive and specific analytical methods in compliance with GLP guidelines.
• Quality Control in Pharmaceutical Manufacturing: Acts as a reference standard for ensuring the purity and consistency of related pharmaceutical compounds or natural product extracts.

Basic Information

Product Name	cis-Urocanic Acid-[13C3]
CAS No.	1173097-34-1
Molecular Formula	C313C3H6N2O2
Molecular Weight	141.10 g/mol (for 13C3 labeled form)
Synonyms	(Z)-3-(1H-Imidazol-4-yl)acrylic-13C3 Acid; (Z)-Urocanic-13C3 Acid; cis-Imidazole-4-acrylic-13C3 Acid; 4-Imidazoleacrylic-13C3 Acid; (Z)-3-(1H-Imidazol-4-yl)-2-propenoic-13C3 Acid; UCA-13C3; Isotopically Labeled Urocanic Acid
EINECS	Contact for details

Quality Control

Every batch of cis-Urocanic Acid-[13C3] is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, isotopic enrichment, and solvent content are provided. Our quality commitment ensures reliability for your most demanding research and regulatory submission needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Isotopic Purity (MS)	≥ 99% 13C3
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.