Description

3-Methyluric Acid-13C4,15N3 is a stable isotope-labeled analog of a key purine metabolite, essential for advanced analytical research. This compound provides the internal standard necessary for achieving high-precision quantification in mass spectrometry-based assays. It is primarily required by pharmaceutical, clinical research, and diagnostic laboratories for method development and validation in metabolomics and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous 3-methyluric acid and related purine metabolites in biological matrices like plasma, urine, and tissue samples.
• Metabolomics Research: Enables precise tracking and measurement of metabolic pathways, particularly those involving xanthine oxidase activity and purine catabolism.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in studies to understand the metabolic fate of drugs that influence or are processed through purine metabolic pathways.
• Clinical Diagnostics Development: Serves as a reference standard in the development of assays for metabolic disorders, such as those related to oxidative stress or impaired renal function.
• Isotope Dilution Mass Spectrometry (IDMS): The gold-standard technique for achieving definitive methods in analytical chemistry, requiring high-purity labeled standards like this compound.
• Biomarker Discovery and Validation: Facilitates the reliable identification and quantification of 3-methyluric acid as a potential biomarker in various disease states.

Basic Information

Product Name	3-Methyluric Acid-13C4,15N3
CAS No.	1173019-10-7
Molecular Formula	C13C4H615N3O3
Molecular Weight	~199.10 g/mol (labeled)
Synonyms	1,3,7-Trimethyluric acid-13C4,15N3; 3-Methyluric acid-13C4,15N3; 1,3,7-Trimethyl-2,6,8-trioxopurine-13C4,15N3; 3-Methyl-2,6,8-trioxopurine-13C4,15N3; TMUA-13C4,15N3; [13C4,15N3]-3-Methyluric Acid; Isotopically Labeled 3-Methyluric Acid; Stable Isotope-Labeled Internal Standard (SIL-IS) for 3-Methyluric Acid
EINECS	Contact for details

Quality Control

Every batch of 3-Methyluric Acid-13C4,15N3 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment, and impurity profile is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.