Description

5-Iodo-2,3-Difluorobenzoic Acid Methyl Ester is a high-purity, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring iodine and fluorine substituents, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on new active ingredients, particularly in the areas of medicinal chemistry and crop protection.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine and iodine motifs for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialty polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on aromatic systems and reaction pathways.
• Radiopharmaceutical Labeling: Potential precursor for compounds where the iodine-127 can be exchanged for radioactive isotopes like iodine-124 or iodine-131 for diagnostic or therapeutic applications.

Basic Information

Product Name	5-Iodo-2,3-Difluorobenzoic Acid Methyl Ester
CAS No.	1163692-49-6
Molecular Formula	C8H5F2IO2
Molecular Weight	298.03 g/mol
Synonyms	Methyl 5-Iodo-2,3-difluorobenzoate; 2,3-Difluoro-5-iodobenzoic Acid Methyl Ester; Benzoic acid, 5-iodo-2,3-difluoro-, methyl ester; Methyl 2,3-difluoro-5-iodobenzoate
EINECS	Contact for details

Quality Control

Our 5-Iodo-2,3-Difluorobenzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.