Description

Fmoc-Leu-Oh-13C6,15N is a stable isotope-labeled derivative of the amino acid leucine, specifically designed for advanced research and analytical applications. This compound is essential for quantitative proteomics and metabolic studies, where it serves as a critical internal standard for mass spectrometry, enabling precise and accurate measurement of protein expression and turnover rates. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in biomarker discovery and peptide synthesis.

Application

• As an internal standard in quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) for proteomic analysis.
• For metabolic flux analysis and metabolic pathway studies in cell culture and biological systems.
• In the synthesis of isotopically labeled peptides and proteins for structural biology and biophysical studies.
• As a key reagent in pharmaceutical research for drug metabolism and pharmacokinetics (DMPK) studies.
• For use in clinical research and biomarker validation to ensure analytical accuracy and reproducibility.
• In the development and validation of diagnostic assays requiring high-precision isotopic labels.

Basic Information

Product Name	Fmoc-Leu-Oh-13C6,15N
CAS No.	1163133-36-5
Molecular Formula	C21H1713C615NO4
Molecular Weight	Contact for details
Synonyms	Fmoc-L-leucine-13C6,15N; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine-13C6,15N; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-methyl-13C6,15N-pentanoic acid; Fmoc-Leu-OH (13C6, 15N); Isotopically labeled Fmoc-Leucine; Fmoc-13C6,15N-Leu-OH; Stable isotope-labeled Fmoc protected leucine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Leu-Oh-13C6,15N is produced and tested under strict quality management systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % 15N
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.