Description

2-{Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphino}-3,6-Dimethoxy-2′,4′,6′-Triisopropyl-1,1′-Biphenyl is a highly specialized, electron-rich phosphine ligand crucial for modern cross-coupling catalysis. Its value lies in enabling challenging transformations, particularly for the synthesis of complex pharmaceutical intermediates and advanced materials, by providing exceptional steric bulk and electron-donating properties. This ligand, supplied at a minimum purity of 95%, is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to optimize palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations.

Application

• Pharmaceutical Intermediate Synthesis: A key ligand for palladium-catalyzed C–N (Buchwald-Hartwig) and C–C (Suzuki-Miyaura) bond formation in API manufacturing.
• Agrochemical Research: Used in the catalytic synthesis of novel, complex active ingredients requiring selective coupling reactions.
• Materials Science: Facilitates the construction of conjugated organic frameworks and specialty polymers via cross-coupling methodologies.
• Process Chemistry & Scale-Up: Enables more efficient and robust catalytic processes for industrial-scale production of fine chemicals.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel chemical space in discovery chemistry.
• Catalyst Precursor Formation: Used to generate highly active, well-defined palladium complexes for homogeneous catalysis.

Basic Information

Product Name	2-{Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphino}-3,6-Dimethoxy-2′,4′,6′-Triisopropyl-1,1′-Biphenyl (95%)
CAS No.	1160861-60-8
Molecular Formula	C46H42F12O2P
Molecular Weight	876.79 g/mol
Synonyms	BrettPhos; 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl (common misnomer for related ligand); RuPhos (common misnomer for related ligand); XPhos (common misnomer for related ligand); 2-(Bis(3,5-bis(trifluoromethyl)phenyl)phosphino)-3,6-dimethoxy-2',4',6'-triisopropylbiphenyl; BrettPhos Ligand; 2-Dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl (incorrect but frequently searched); Biarylphosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our BrettPhos ligand undergoes rigorous analytical testing to ensure it meets the high standards required for sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to support cGMP-compliant manufacturing for pharmaceutical customers, ensuring traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Palladium (Pd) Content	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.