Description

2-(Di-1-Adamantylphosphino)-3,6-Dimethoxy-2',4',6'-Tri-I-Propyl-1,1'-Biphenyl, Min. 95% Adbrettphos CAS NO 1160861-59-5 is a highly specialized, sterically demanding monodentate phosphine ligand designed for challenging cross-coupling and other transition metal-catalyzed reactions. Its value lies in providing exceptional stability and selectivity to catalytic systems, enabling more efficient synthesis of complex pharmaceutical intermediates and advanced materials. This ligand is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to optimize catalytic performance.

Application

• As a ligand in palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings.
• Catalyst component for the synthesis of complex, sterically hindered biaryl compounds prevalent in drug discovery.
• Enabling technology for late-stage functionalization of pharmaceutical intermediates under mild conditions.
• Use in the development of high-performance materials through precise catalytic polymerization or oligomerization.
• Research and development of novel catalytic cycles in academic and industrial settings.
• Potential application in asymmetric catalysis when used in conjunction with chiral auxiliaries or metal centers.

Basic Information

Product Name	2-(Di-1-Adamantylphosphino)-3,6-Dimethoxy-2',4',6'-Tri-I-Propyl-1,1'-Biphenyl, Min. 95% Adbrettphos CAS NO 1160861-59-5
CAS No.	1160861-59-5
Molecular Formula	C45H61O2P
Molecular Weight	664.94 g/mol
Synonyms	AdBrettPhos; 2-(Diadamantylphosphino)-3,6-dimethoxy-2',4',6'-triisopropylbiphenyl; 2-(Bis(adamantan-1-yl)phosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl; BrettPhos-type ligand; AdBrettphos ligand; cataCXium® AdBrettphos; Di-1-adamantyl(3,6-dimethoxy-2',4',6'-triisopropyl[1,1'-biphenyl]-2-yl)phosphine
EINECS	Contact for details

Quality Control

Our production of AdBrettphos adheres to stringent in-process controls to ensure batch-to-batch consistency and a minimum purity of 95%. Identity and purity are confirmed by a combination of NMR (1H, 13C, 31P), HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The compound is easily oxidized and moisture-sensitive; therefore, the container should be flushed with inert gas after each opening and stored in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	Min. 95.0%
31P NMR Purity	Min. 95.0%
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.