Description

1',4-Bis(T-Butyl)-1,2,3'-Tris(Diphenylphosphino)Ferrocene, 98% Hiersophos-2 CAS NO 1159850-42-6 is a high-purity, chiral ferrocenyl phosphine ligand designed for advanced asymmetric catalysis. This compound matters because it provides exceptional stereoselectivity and stability in demanding cross-coupling and hydrogenation reactions, enabling the synthesis of complex chiral molecules. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for scalable, enantioselective synthesis.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Negishi, and Buchwald-Hartwig amination reactions to construct C-C and C-N bonds with high enantiomeric excess.
• Pharmaceutical Process Development: Used in the research and scale-up manufacturing of active pharmaceutical ingredients (APIs) requiring specific chirality.
• Agrochemical Synthesis: Facilitates the production of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Production: Enables the creation of enantiomerically pure flavors, fragrances, and specialty chemicals.
• Academic and Industrial R&D: A valuable tool for methodology development in organometallic chemistry and catalysis research.
• Material Science Precursors: Potential use in synthesizing chiral polymers or metal-organic frameworks (MOFs) with specific electronic properties.

Basic Information

Product Name	1',4-Bis(T-Butyl)-1,2,3'-Tris(Diphenylphosphino)Ferrocene, 98% Hiersophos-2
CAS No.	1159850-42-6
Molecular Formula	C58H58FeP3
Molecular Weight	912.83 g/mol
Synonyms	Hiersophos-2; 1',4-Bis(tert-Butyl)-1,2,3'-Tris(diphenylphosphino)ferrocene; Tris(diphenylphosphino)ferrocene derivative; Josiphos-type ligand; Chiral ferrocenylphosphine; (R)- or (S)-1',4-Bis(tert-butyl)-1,2,3'-tris(diphenylphosphino)ferrocene; Asymmetric diphosphine ligand; FERRROCENE, 1',4-BIS(1,1-DIMETHYLETHYL)-1,2,3'-TRIS(DIPHENYLPHOSPHINO)-
EINECS	Contact for details

Quality Control

Our 1',4-Bis(T-Butyl)-1,2,3'-Tris(Diphenylphosphino)Ferrocene is produced and tested to meet stringent quality standards. Each batch undergoes rigorous analytical characterization, including NMR (1H, 13C, 31P), HPLC for purity, and chiral analysis to confirm enantiomeric purity where applicable. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and moisture-sensitive; ensure the container is sealed immediately after use and stored in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specified enantiomer)
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.