Description

Methyl 3-(Chlorosulfonyl)-5-Fluorobenzoate is a high-purity, multi-functional chemical intermediate designed for advanced synthesis. This compound is critical for introducing both a reactive sulfonyl chloride group and a fluorinated aromatic moiety into target molecules, enabling precise structural modifications. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized monomers or additives in specialty polymers and advanced materials.
• Chemical Biology Probes: Employed in the creation of activity-based probes and labeling reagents for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A versatile starting material for custom chemical synthesis and scale-up projects under cGMP or ISO standards.

Basic Information

Product Name	Methyl 3-(Chlorosulfonyl)-5-Fluorobenzoate
CAS No.	1155909-75-3
Molecular Formula	C8H6ClFO4S
Molecular Weight	252.65 g/mol
Synonyms	5-Fluoro-3-(chlorosulfonyl)benzoic acid methyl ester; Methyl 5-fluoro-3-(chlorosulfonyl)benzoate; 3-(Chlorosulfonyl)-5-fluorobenzoic acid methyl ester; Benzoic acid, 5-fluoro-3-(chlorosulfonyl)-, methyl ester; Methyl 3-chlorosulfonyl-5-fluorobenzoate; 1155909-75-3; 5-Fluoro-3-sulfonylchloride-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-(Chlorosulfonyl)-5-Fluorobenzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.