Description

4-Amino-2-Chloro-3-Fluorobenzeneboronic Acid Pinacol Ester, 96% is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Useful for synthesizing tagged molecules for studying biological processes and target engagement.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-Amino-2-Chloro-3-Fluorobenzeneboronic Acid Pinacol Ester, 96%
CAS No.	1154740-65-4
Molecular Formula	C₁₂H₁₆BClFNO₂
Molecular Weight	271.52 g/mol
Synonyms	4-Amino-2-chloro-3-fluorophenylboronic acid pinacol ester; 2-Chloro-3-fluoro-4-aminophenylboronic acid pinacol ester; (4-Amino-2-chloro-3-fluorophenyl)boronic acid pinacol ester; B-(4-Amino-2-chloro-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(4-amino-2-chloro-3-fluorophenyl)-1,3,2-dioxaborolane; Pinacol (4-Amino-2-chloro-3-fluorophenyl)boronate; CAS 1154740-65-4
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Chloro-3-Fluorobenzeneboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed to confirm identity, purity, and impurity profile. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The product is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 96.0%
Purity (HPLC, Area%)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.