Description

Methyl 4-(Difluoromethoxy)-3-Nitrobenzoate is a high-purity, advanced pharmaceutical intermediate characterized by its difluoromethoxy and nitro-substituted benzoate structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise fluorination for enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries engaged in developing novel small-molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of advanced herbicides and pesticides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, including reduction of the nitro group or hydrolysis of the ester to access carboxylic acid derivatives.
• Material Science: Potential use in the research and development of specialty polymers and liquid crystals due to its aromatic and fluorinated structure.

Basic Information

Product Name	Methyl 4-(Difluoromethoxy)-3-Nitrobenzoate
CAS No.	1154278-25-7
Molecular Formula	C9H7F2NO5
Molecular Weight	247.15 g/mol
Synonyms	3-Nitro-4-(difluoromethoxy)benzoic acid methyl ester; Methyl 3-nitro-4-(difluoromethoxy)benzoate; Benzoic acid, 4-(difluoromethoxy)-3-nitro-, methyl ester; 4-(Difluoromethoxy)-3-nitrobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-(Difluoromethoxy)-3-Nitrobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.