Description

5-Chloro-2-Fluoro-3-Nitro-Benzoic Acid Methyl Ester is a high-purity, multi-functional chemical intermediate essential for advanced organic synthesis. Its unique halogenated and nitrated benzoate structure makes it a valuable building block for constructing complex molecules with specific electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core.
• Liquid Crystal & OLED Material Research: Serves as a building block for advanced electronic materials due to its potential for modifying molecular polarity and conjugation.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized colorants and photographic chemicals where nitro and ester functionalities are required.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploring new chemical spaces.

Basic Information

Product Name	5-Chloro-2-Fluoro-3-Nitro-Benzoic Acid Methyl Ester
CAS No.	1153285-33-6
Molecular Formula	C8H5ClFNO4
Molecular Weight	233.58 g/mol
Synonyms	Methyl 5-Chloro-2-Fluoro-3-Nitrobenzoate; Benzoic acid, 5-chloro-2-fluoro-3-nitro-, methyl ester; 3-Nitro-5-chloro-2-fluorobenzoic acid methyl ester; 2-Fluoro-5-chloro-3-nitrobenzoic acid methyl ester; Methyl 2-fluoro-5-chloro-3-nitrobenzoate; 1153285-33-6; 5-Chloro-2-fluoro-3-nitro methyl benzoate
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-3-Nitro-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high standards, including cGMP intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.