Description

2-(2-Chlorophenyl)-2,2-Difluoroacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoroacetate moiety adjacent to a chlorinated phenyl ring, enabling precise molecular modifications. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with tailored electronic or surface properties.
• Fluorine Chemistry Studies: An important reagent for academic and industrial research exploring new methodologies in fluorination and difluoromethylation chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	2-(2-Chlorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1150164-78-5
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2,2-Difluoro-2-(2-chlorophenyl)acetic Acid; α,α-Difluoro-o-chlorophenylacetic Acid; (2-Chlorophenyl)difluoroacetic Acid; 2-(2-Chlorophenyl)-2,2-difluoroethanoic Acid; o-Chlorophenyl-difluoroacetic Acid; 2-Chloro-α,α-difluorobenzeneacetic Acid; CAS 1150164-78-5
EINECS	Contact for details

Quality Control

Our 2-(2-Chlorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.