Description

2-(5-(Difluoromethyl)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and versatile building block in modern synthetic chemistry. Its core value lies in its role as a key pinacol boronic ester, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing novel active ingredients and functional molecules. Its specific substitution pattern offers unique reactivity and selectivity in demanding synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides that require specific fluorinated chemical architectures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as those used in OLEDs and semiconductors, where fluorine substitution tunes electronic properties.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a stable, reactive boronic ester partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library development for high-throughput screening in the search for new drug candidates.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	2-(5-(Difluoromethyl)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1142228-23-6
Molecular Formula	C₁₃H₁₆BF₃O₂
Molecular Weight	272.08 g/mol
Synonyms	2-(5-(Difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-(Difluoromethyl)-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-5-(difluoromethyl)phenylboronic acid pinacol ester; Pinacol [2-fluoro-5-(difluoromethyl)phenyl]boronate; [2-Fluoro-5-(difluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1142228-23-6; B-2-Fluoro-5-(difluoromethyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 2-(5-(Difluoromethyl)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates, ensuring the material meets the rigorous standards required for pharmaceutical development and commercial manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.