Description

n-Isopropyl-L-Proline is a high-purity, non-proteinogenic amino acid derivative featuring a proline scaffold with an isopropyl substituent on the nitrogen atom. This chiral building block is critical for the synthesis of complex molecules where precise stereochemistry and specific spatial orientation are required. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and central nervous system (CNS) disorders.
• Peptide Chemistry: Used to introduce conformational constraints and enhance the metabolic stability, potency, and selectivity of therapeutic peptides.
• Asymmetric Synthesis: Serves as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce high enantioselectivity.
• Protease Inhibitor Design: Incorporated into the structure of inhibitors targeting proteolytic enzymes like prolyl oligopeptidase.
• Chemical Biology Research: Employed as a molecular probe to study enzyme-substrate interactions and protein function.
• Agrochemical Research: Potential intermediate in the synthesis of advanced, chiral crop protection agents.

Basic Information

Product Name	n-Isopropyl-L-Proline
CAS No.	1141826-51-8
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	L-Proline, N-(1-methylethyl)-; (S)-1-Isopropylpyrrolidine-2-carboxylic acid; N-Isopropyl-L-proline; 1-Isopropyl-L-proline; N-Isopropyl-(S)-proline; 1141826-51-8; L-N-Isopropylproline
EINECS	Contact for details

Quality Control

Our n-Isopropyl-L-Proline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.