Description

4-Chlorothiophene-2-Boronic Acid is a versatile organoboron building block, specifically a heterocyclic boronic acid derivative. This compound is highly valued in modern synthetic chemistry for its role in facilitating carbon-carbon bond formation via cross-coupling reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex thiophene-containing molecules, which are prevalent in active pharmaceutical ingredients and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing novel drug candidates, particularly those containing functionalized thiophene cores.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides that incorporate chlorinated thiophene motifs for enhanced biological activity.
• Material Science Research: Serves as a monomer or building block for creating conjugated polymers and organic electronic materials, such as those used in organic light-emitting diodes (OLEDs) or semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-Chlorothiophene-2-Boronic Acid
CAS No.	1133931-02-8
Molecular Formula	C4H4BClO2S
Molecular Weight	162.40 g/mol
Synonyms	(4-Chloro-2-thienyl)boronic acid; 4-Chloro-2-thiopheneboronic acid; 4-Chlorothiophene-2-boronic acid pinacol ester (protected form); 2-Borono-4-chlorothiophene; 4-Chloro-2-thienylboronic acid; B-(4-Chloro-2-thienyl)boronic acid
EINECS	Contact for details

Quality Control

Our 4-Chlorothiophene-2-Boronic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, NMR for structural confirmation, and Karl Fischer titration for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality systems are designed to meet the stringent demands of cGMP and ISO standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.