Description

Cyclopropanemethanamine, α-(Trifluoromethyl)-, (αr)- is a high-value, chiral amine building block characterized by its cyclopropane and trifluoromethyl functional groups. This compound matters for its role in advanced pharmaceutical and agrochemical research, where its unique stereochemistry and fluorine substitution are leveraged to modulate the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides, where the cyclopropane and trifluoromethyl groups enhance efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored properties, utilizing its rigid cyclic structure.
• Chemical Biology Probe: Utilized as a building block for creating molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-up: A critical intermediate for process optimization and the commercial-scale manufacturing of fine chemicals.

Basic Information

Product Name	Cyclopropanemethanamine, α-(Trifluoromethyl)-, (αr)-
CAS No.	1131737-04-6
Molecular Formula	C5H8F3N
Molecular Weight	139.12 g/mol
Synonyms	(R)-1-Cyclopropyl-2,2,2-trifluoroethanamine; (R)-α-(Trifluoromethyl)cyclopropanemethylamine; (R)-1-Cyclopropyl-2,2,2-trifluoroethylamine; (R)-2,2,2-Trifluoro-1-cyclopropylethanamine; (R)-α-(Trifluoromethyl)cyclopropanemethanamine; (R)-Cyclopropanemethanamine, α-(trifluoromethyl)-; (R)-1-(Trifluoromethyl)cyclopropylmethylamine
EINECS	Contact for details

Quality Control

Our Cyclopropanemethanamine, α-(Trifluoromethyl)-, (αr)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent specifications for research and development use. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to light or air should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.