Description

4-(Difluoromethoxy)-3-Iodobenzoic Acid is a high-value, multi-functional halogenated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring both difluoromethoxy and iodine substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting metabolic and central nervous system disorders.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, where the difluoromethoxy group can enhance bioavailability and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science: Building block for specialty polymers and liquid crystals, where halogen atoms influence electronic properties and mesophase behavior.
• Chemical Biology: Useful as a probe or tag in bioconjugation chemistry due to the reactivity of the iodine atom.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects and scale-up campaigns.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Iodobenzoic Acid
CAS No.	1131588-14-1
Molecular Formula	C8H5F2IO3
Molecular Weight	313.03 g/mol
Synonyms	3-Iodo-4-(difluoromethoxy)benzoic Acid; Benzoic acid, 4-(difluoromethoxy)-3-iodo-; 4-(Difluoromethoxy)-3-iodobenzoic acid; 1131588-14-1; 3-Iodo-4-difluoromethoxybenzoic acid; 4-Difluoromethoxy-3-iodobenzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-3-Iodobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality. We support custom purity requirements and can provide material compliant with ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.