Description

4-(Difluoromethyl)-3-Iodobenzoic Acid is a high-value, multi-functional aromatic building block featuring both a difluoromethyl group and an iodine substituent on the benzoic acid core. This compound matters for its unique reactivity profile, where the iodine atom serves as an excellent handle for cross-coupling reactions, while the difluoromethyl group imparts desirable physicochemical properties to target molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for introducing fluorinated motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing properties of fluorine.
• Material Science: Serves as a precursor for advanced organic materials, including liquid crystals and polymers with tailored electronic properties.
• Cross-Coupling Reactions: The iodine atom is pivotal in metal-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings for constructing complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for studying the effects of difluoromethylation on molecular conformation and metabolic stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development candidates.

Basic Information

Product Name	4-(Difluoromethyl)-3-Iodobenzoic Acid
CAS No.	1131588-05-0
Molecular Formula	C8H5F2IO2
Molecular Weight	297.99 g/mol
Synonyms	3-Iodo-4-(difluoromethyl)benzoic Acid; Benzoic acid, 4-(difluoromethyl)-3-iodo-; 4-(Difluoromethyl)-3-iodobenzoic acid; 1131588-05-0; 3-Iodo-4-difluoromethylbenzoic acid; 4-Difluoromethyl-3-iodobenzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)-3-Iodobenzoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.