Description

3,5-Difluoro-4-Nitrobenzoic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and carboxylic acid groups on a difluorinated benzene ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated aromatic core to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, contributing to improved charge transport and thermal stability in displays and lighting.
• Cross-Coupling Reactions: The carboxylic acid and halogenated aryl groups make it a suitable substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid functionality allows for amide bond formation, enabling its use in creating fluorinated peptide analogs or as a linker in bioconjugation chemistry.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and as a standard in analytical chemistry.

Basic Information

Product Name	3,5-Difluoro-4-Nitrobenzoic Acid
CAS No.	1131580-60-3
Molecular Formula	C7H3F2NO4
Molecular Weight	203.10 g/mol
Synonyms	4-Nitro-3,5-difluorobenzoic Acid; Benzoic acid, 3,5-difluoro-4-nitro-; 3,5-Difluoro-4-nitro-benzoic acid; 3,5-Difluoro-4-nitrobenzoic acid; 2,6-Difluoro-4-carboxynitrobenzene
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-4-Nitrobenzoic Acid is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.