Description

(R)-1-(4-Chloro-3-Fluorophenyl)Ethanamine is a high-purity chiral amine building block of significant importance in modern pharmaceutical and agrochemical research. Its value lies in its role as a key intermediate for synthesizing enantiomerically pure active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is essential for R&D chemists and process development scientists working in pharmaceutical development, agrochemical synthesis, and advanced material science.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel small-molecule drugs, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure herbicides, fungicides, and insecticides for enhanced efficacy and environmental safety.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the synthesis of specialty polymers and liquid crystals where specific stereochemistry is required.
• Chemical Reference Standard: Utilized as a high-purity standard for analytical method development and quality control in regulatory submissions.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	(R)-1-(4-Chloro-3-Fluorophenyl)Ethanamine
CAS No.	1114559-14-6
Molecular Formula	C8H9ClFN
Molecular Weight	173.61 g/mol
Synonyms	(R)-1-(4-Chloro-3-fluorophenyl)ethan-1-amine; (R)-α-Methyl-4-chloro-3-fluoro-benzylamine; (R)-1-(4-Chloro-3-fluorophenyl)ethylamine; (R)-4-Chloro-3-fluoro-α-methylbenzylamine; (R)-1-Aminoethyl-4-chloro-3-fluorobenzene; (R)-1-(4-Chloro-3-fluorophenyl)ethanamine hydrochloride (salt form); (R)-CEFA
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Chloro-3-Fluorophenyl)Ethanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.