Description

4,4,5,5-Tetramethyl-2-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane is a high-purity, fluorinated boronic ester derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stable, reactive handle for the introduction of a highly fluorinated aryl moiety via cross-coupling reactions, enabling the development of novel materials with unique properties. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty materials industries, particularly for creating molecules with enhanced metabolic stability, lipophilicity, and electronic characteristics.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key precursor for constructing complex biaryl systems containing perfluoroalkyl and polyfluoroaryl groups in pharmaceutical intermediates.
• Pharmaceutical Research: Used in the synthesis of active pharmaceutical ingredients (APIs) and candidates where fluorination is employed to modulate bioavailability, potency, and metabolic stability.
• Agrochemical Development: Integral for creating novel herbicides, fungicides, and insecticides that benefit from the chemical and thermal stability imparted by the fluorinated aromatic ring.
• Organic Light-Emitting Diodes (OLEDs): Serves as a monomer or intermediate in the production of electron-transport or host materials for high-performance display and lighting technologies.
• Liquid Crystal & Polymer Synthesis: Used to incorporate fluorinated aromatic units into liquid crystal molecules and high-performance polymers to tailor their dielectric constant, refractive index, and chemical resistance.
• Material Science: Employed in the development of advanced coatings, surfactants, and specialty chemicals that require specific surface energy and oleophobic/hydrophobic properties.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane
CAS No.	1111096-06-0
Molecular Formula	C13H12BF7O2
Molecular Weight	332.04 g/mol
Synonyms	2-(2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(perfluoro-4-(trifluoromethyl)phenyl)-1,3,2-dioxaborolane; (2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; Pinacol [2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]boronate; [4-(Trifluoromethyl)-2,3,5,6-tetrafluorophenyl]boronic acid pinacol ester; CAS 1111096-06-0; Fluorinated aryl pinacol boronate ester
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and maintain stability. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.