Description

Benzoic Acid, 2-Amino-5-(Trifluoromethyl)-, Ethyl Ester is a high-purity, trifluoromethyl-substituted aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique structural features, combining an amino group and a highly electron-withdrawing trifluoromethyl group on a benzoate ester scaffold, which are critical for modulating the physicochemical properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where its fluorine-containing motif can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorine-containing organic electronic materials for displays and lighting applications.
• Advanced Polymer Modifiers: Incorporated as a specialty monomer to introduce fluorine functionality into polymers, altering surface properties and chemical resistance.
• Chemical Research & Development: A versatile building block in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and route scouting.
• Fluorine Chemistry Reagent: Employed in methodological development for introducing fluorinated aromatic systems into more complex molecular architectures.

Basic Information

Product Name	Benzoic Acid, 2-Amino-5-(Trifluoromethyl)-, Ethyl Ester
CAS No.	1108668-05-8
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	Ethyl 2-Amino-5-(trifluoromethyl)benzoate; 2-Amino-α,α,α-trifluoro-p-toluic Acid Ethyl Ester; 5-(Trifluoromethyl)anthranilic Acid Ethyl Ester; Ethyl 5-(Trifluoromethyl)anthranilate; 2-Amino-5-trifluoromethylbenzoic Acid Ethyl Ester; Benzoic acid, 2-amino-5-(trifluoromethyl)-, ethyl ester; Ethyl 2-amino-α,α,α-trifluoro-p-toluate
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 2-Amino-5-(Trifluoromethyl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.