Description

2-Trifluoromethoxy-5-Fluorobenzoic Acid is a high-value fluorinated benzoic acid derivative characterized by its unique trifluoromethoxy and fluorine substituents. This compound serves as a critical pharmaceutical intermediate and advanced building block in organic synthesis, enabling the introduction of lipophilic and electron-withdrawing groups. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS, oncology, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorinated aromatic core enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and thermal stability.
• Organic Synthesis Building Block: Employed in coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and carboxylate derivatization to create complex molecules for research and scale-up.
• Coordination Chemistry Ligand: The carboxylic acid functionality allows it to act as a ligand or precursor for metal-organic frameworks (MOFs) and catalysts.

Basic Information

Product Name	2-Trifluoromethoxy-5-Fluorobenzoic Acid
CAS No.	1092460-83-7
Molecular Formula	C8H4F4O3
Molecular Weight	224.11 g/mol
Synonyms	5-Fluoro-2-(trifluoromethoxy)benzoic Acid; 2-(Trifluoromethoxy)-5-fluorobenzoic Acid; 5-Fluoro-α,α,α-trifluoro-o-anisic Acid; Benzoic acid, 5-fluoro-2-(trifluoromethoxy)-; 1092460-83-7; 2-Trifluoromethoxy-5-fluorobenzoic acid; 5-Fluoro-2-trifluoromethoxybenzoic acid
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethoxy-5-Fluorobenzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.