Description

3,5-Difluoro-2-Methoxycinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in the strategic incorporation of fluorine and methoxy groups, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced efficacy.
• Liquid Crystal & OLED Material Precursor: Serves as a core structure for synthesizing fluorinated organic electronic materials.
• Chemical Biology Probe Development: Employed to create fluorescent tags or molecular probes for studying biological processes.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Peptide Mimetics & Bioisosteres: The cinnamic acid scaffold is utilized to design and synthesize peptide analogs and bioisosteric replacements.

Basic Information

Product Name	3,5-Difluoro-2-Methoxycinnamic Acid
CAS No.	1092460-61-1
Molecular Formula	C₁₀H₈F₂O₃
Molecular Weight	214.17 g/mol
Synonyms	(E)-3-(3,5-Difluoro-2-methoxyphenyl)acrylic acid; 3,5-Difluoro-2-methoxycinnamate; 2-Methoxy-3,5-difluorocinnamic Acid; (2E)-3-(3,5-Difluoro-2-methoxyphenyl)-2-propenoic Acid; trans-3,5-Difluoro-2-methoxycinnamic Acid; 3,5-Difluoro-o-methoxycinnamic Acid; 1092460-61-1; DFMOCA
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Methoxycinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.