Description

n-[(8α,9S)-6'-Methoxycinchonan-9-Yl]-3,5-Bis(Trifluoromethyl)-Benzenesulfonamide is a high-value, organocatalytic intermediate derived from the cinchona alkaloid family, known for its role in facilitating highly selective asymmetric synthesis. This compound matters to industries requiring precise stereochemical control, as it enables the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel chiral compounds and catalysts.

Application

• Asymmetric Organocatalysis: Serves as a privileged chiral scaffold for the development of novel catalysts used in enantioselective C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) that require specific stereochemistry for efficacy and safety.
• Chiral Ligand Synthesis: Used to prepare sophisticated ligands for transition metal catalysis in fine chemical production.
• Agrochemical Research: Employed in the development of enantiomerically pure pesticides and herbicides to enhance activity and reduce environmental impact.
• Academic & Process R&D: A critical reagent for methodological development in synthetic organic chemistry and scale-up process optimization.
• Material Science: Potential use in creating chiral polymers or surfaces with specific optical or recognition properties.

Basic Information

Product Name	n-[(8α,9S)-6'-Methoxycinchonan-9-Yl]-3,5-Bis(Trifluoromethyl)-Benzenesulfonamide
CAS No.	1092116-26-1
Molecular Formula	C₂₉H₂₆F₆N₂O₃S
Molecular Weight	596.59 g/mol
Synonyms	(8α,9S)-N-[6'-Methoxycinchonan-9-yl]-3,5-bis(trifluoromethyl)benzenesulfonamide; Cinchona Alkaloid Sulfonamide Derivative; 3,5-Bis(trifluoromethyl)-N-[(8α,9S)-6'-methoxycinchonan-9-yl]benzenesulfonamide; (8α,9S)-9-[[[3,5-Bis(trifluoromethyl)phenyl]sulfonyl]amino]-6'-methoxycinchonane; Chiral Cinchona Sulfonamide; Organocatalyst Intermediate 1092116-26-1; Cinchonidine-based Sulfonamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (HPLC), and residual solvent content are available upon request. We adhere to cGMP principles for production relevant to pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.