Description

5-Fluoro-2-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid is a high-purity, advanced pharmaceutical intermediate and a versatile boronic ester building block. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced properties.
• Material Science: Potential use in the synthesis of organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Chemical Biology: Employed in the creation of probes and tool compounds for studying biological systems and drug discovery.
• Custom Synthesis: A critical starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Product Name	5-Fluoro-2-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid
CAS No.	1084953-16-1
Molecular Formula	C₁₄H₁₈BFO₅
Molecular Weight	296.10 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoro-2-methoxybenzoic acid; 5-Fluoro-2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 2-Methoxy-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; Benzoic acid, 5-fluoro-2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 5-Fluoro-2-methoxy-4-boronobenzoate; 5-Fluoro-2-methoxy-4-boronobenzoic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.