Description

(1R)-1-[4-Chloro-3-(Trifluoromethyl)Phenyl]Ethylamine is a high-purity chiral amine building block of significant importance in advanced organic synthesis. Its value lies in its unique molecular architecture, featuring a trifluoromethyl group and a chiral center, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require sophisticated intermediates for the development of new active ingredients.

Application

This chiral amine serves as a versatile intermediate in the synthesis of complex molecules. Its primary applications include:

• Pharmaceutical Intermediate: A key chiral building block for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Material Science Research: Acts as a precursor for specialty monomers or functional materials that require specific fluorinated aromatic components.
• Chemical Biology Probes: Useful for creating labeled compounds or probes for studying biological mechanisms and target engagement.

Basic Information

Item	Details
Product Name	(1R)-1-[4-Chloro-3-(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	1080064-51-2
Molecular Formula	C9H9ClF3N
Molecular Weight	223.62 g/mol
Synonyms	(R)-1-(4-Chloro-3-(trifluoromethyl)phenyl)ethan-1-amine; (R)-1-(4-Chloro-3-(trifluoromethyl)phenyl)ethylamine; (1R)-1-[4-Chloro-3-(trifluoromethyl)phenyl]ethanamine; (R)-α-Methyl-4-chloro-α-(trifluoromethyl)benzenemethanamine; (R)-4-Chloro-α-(trifluoromethyl)benzeneethanamine; (R)-1-(4-Chloro-3-trifluoromethyl-phenyl)-ethylamine
EINECS	Contact for details

Quality Control

Our (1R)-1-[4-Chloro-3-(Trifluoromethyl)Phenyl]Ethylamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.