Description

Zamicastat is a high-purity, small molecule pharmaceutical intermediate with the CAS registry number 1080028-80-3. This compound is of significant interest for its role in the research and development of novel therapeutic agents, particularly within the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced drug synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational new drugs targeting neurological pathways.
• Research & Development: Used in preclinical and clinical research studies to explore new mechanisms of action and therapeutic applications.
• Reference Standard: Serves as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Chemical Synthesis: Employed in custom synthesis and process development for creating complex molecular structures in medicinal chemistry.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies.

Basic Information

Product Name	Zamicastat
CAS No.	1080028-80-3
Molecular Formula	C17H19N3O2S
Molecular Weight	329.42 g/mol
Synonyms	Zamicastat; (R)-N-(2,3-Dihydro-1H-inden-2-yl)-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)acetamide; (R)-2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,3-dihydro-1H-inden-2-yl)acetamide; BIA 5-453; BIA 5-453; BIA-5-453; BIA 5453; (2R)-N-(2,3-Dihydro-1H-inden-2-yl)-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)acetamide
EINECS	Contact for details

Quality Control

Our Zamicastat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.