Description

2,4-Difluorophenylboronic Acid, Propanediol Cyclic Ester is a high-purity, protected boronic acid derivative designed for advanced synthetic chemistry. This compound matters as a critical building block in cross-coupling reactions, offering enhanced stability and handling characteristics compared to its free boronic acid counterpart. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and this protected boronate ester.
• Pharmaceutical Intermediate Synthesis: Used in the research and production of drug candidates, especially those containing difluorophenyl motifs.
• Agrochemical Development: Serves as a building block for creating novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands, and advanced polymers.
• Process Chemistry & Scale-up: Its cyclic ester form offers improved stability for handling in large-scale manufacturing processes.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	2,4-Difluorophenylboronic Acid, Propanediol Cyclic Ester
CAS No.	1073372-07-2
Molecular Formula	C9H9BF2O2
Molecular Weight	197.98 g/mol
Synonyms	2,4-Difluorophenylboronic Acid 1,3-Propanediol Ester; 2-(2,4-Difluorophenyl)-1,3,2-dioxaborinane; 2,4-Difluorophenyl-1,3,2-dioxaborinane; 2,4-Difluorophenylboronic Acid Cyclic Ester; 2,4-Difluorophenylboronic Acid Pinned Ester; 2,4-Difluorophenylboronate 1,3-Propanediol Ester; (2,4-Difluorophenyl)-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 2,4-Difluorophenylboronic Acid, Propanediol Cyclic Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO environments for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.