Description

(3,4-Difluoro-5-Nitrophenyl)Boronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both electron-withdrawing nitro and fluoro substituents, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection agents, leveraging its fluorine and nitro groups for enhanced bioactivity and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and OFETs, where its structural motifs can tune electronic properties.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the development of sensors or inhibitors targeting specific enzymes or proteins.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing novel bidentate ligands used in asymmetric catalysis and transition metal complexes.
• Library Synthesis for High-Throughput Screening: A valuable building block in combinatorial chemistry for generating diverse compound libraries to identify new lead structures.

Basic Information

Product Name	(3,4-Difluoro-5-Nitrophenyl)Boronic Acid
CAS No.	1072952-06-7
Molecular Formula	C6H4BF2NO4
Molecular Weight	202.91 g/mol
Synonyms	3,4-Difluoro-5-nitrobenzeneboronic acid; (3,4-Difluoro-5-nitrophenyl)boronic acid; B-(3,4-Difluoro-5-nitrophenyl)boronic acid; 5-Nitro-3,4-difluorophenylboronic acid; 3,4-Difluoro-5-nitrophenylboronic acid; Boronic acid, B-(3,4-difluoro-5-nitrophenyl)-; 1072952-06-7 (CAS).
EINECS	Contact for details

Quality Control

Our (3,4-Difluoro-5-Nitrophenyl)Boronic Acid is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential decomposition. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.