Description

5-Amino-2,4-Difluorophenylboronic Acid is a high-purity, multifunctional boronic acid derivative characterized by its unique combination of an amino group and fluorine substituents on the aromatic ring. This compound is a critical building block in modern organic synthesis, particularly valued for its role in Suzuki-Miyaura cross-coupling reactions to create complex biaryl structures. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting central nervous system and oncology applications.
• Agrochemical Synthesis: Used in creating novel herbicides and fungicides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed C-C bond formation to construct complex, functionalized biaryl systems.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Utilized to synthesize novel bidentate ligands for metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Acts as a handle for bioconjugation and the development of sensors or inhibitors targeting specific enzymes or receptors.

Basic Information

Product Name	5-Amino-2,4-Difluorophenylboronic Acid
CAS No.	1072952-05-6
Molecular Formula	C6H6BF2NO2
Molecular Weight	172.93 g/mol
Synonyms	(5-Amino-2,4-difluorophenyl)boronic acid; 2,4-Difluoro-5-aminophenylboronic acid; 5-Amino-2,4-difluorobenzeneboronic acid; Boronic acid, B-(5-amino-2,4-difluorophenyl)-; 1072952-05-6; 5-Amino-2,4-difluorophenyl-B(OH)2
EINECS	Contact for details

Quality Control

Our 5-Amino-2,4-Difluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to relevant industry standards to support our customers in pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.