Description

4-(2'-Fluorobenzyloxy)Phenylboronic Acid is a high-purity, functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated benzyloxy moiety that can influence electronic properties and metabolic stability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for creating complex biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Used as a versatile boronic acid coupling partner to form carbon-carbon bonds, enabling the construction of complex, drug-like molecules and functional materials.
• Agrochemical Synthesis: Employed in the research and development of advanced herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and environmental persistence.
• Ligand for Catalyst Systems: Can be utilized in the development of novel ligands for transition metal catalysis due to its electron-withdrawing fluorobenzyloxy group.
• Material Science Research: Serves as a monomer or functional unit in the creation of organic electronic materials, such as polymers for OLEDs or sensors.
• Chemical Biology Probes: Used to create tagged molecules for studying biological processes and protein-ligand interactions.

Basic Information

Product Name	4-(2'-Fluorobenzyloxy)Phenylboronic Acid
CAS No.	1072951-78-0
Molecular Formula	C13H12BFO3
Molecular Weight	246.05 g/mol
Synonyms	[4-(2-Fluorobenzyloxy)phenyl]boronic acid; 2-Fluoro-α-[4-(dihydroxyboranyl)phenoxy]methyl]benzene; 4-(2-Fluorobenzyloxy)benzeneboronic acid; B-[4-[(2-Fluorophenyl)methoxy]phenyl]boronic acid; 4-(2-Fluorobenzyloxy)phenylboronic acid pinacol ester (protected form); 4-(o-Fluorobenzyloxy)phenylboronic acid; (4-((2-Fluorobenzyl)oxy)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-(2'-Fluorobenzyloxy)Phenylboronic Acid is produced under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets specifications suitable for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant methods is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.