Description

2-(Dicyclohexylphosphino)-N,n-Bis(1-Methylethyl)-1H-Indole-1-Carboxamide, Min. 98% Amidole-Phos is a high-purity, specialized organophosphorus ligand designed for advanced catalytic applications. Its value lies in its ability to facilitate challenging cross-coupling and hydrogenation reactions with high selectivity and yield, which is critical for process efficiency in fine chemical synthesis. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance ligands for developing novel compounds and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig amination) for constructing complex drug molecules.
• Agrochemical Production: Enabling the synthesis of novel active ingredients through efficient catalytic cycles.
• Advanced Material Research: Facilitating the creation of specialized polymers and organic electronic materials via metal-catalyzed polymerization.
• Catalyst Development & Screening: Serving as a critical component in catalyst libraries for high-throughput experimentation and process optimization.
• Asymmetric Hydrogenation: Potential use in chiral inducer systems for the production of enantiomerically pure compounds.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research.

Basic Information

Item	Detail
Product Name	2-(Dicyclohexylphosphino)-N,n-Bis(1-Methylethyl)-1H-Indole-1-Carboxamide, Min. 98% Amidole-Phos
CAS No.	1067175-36-3
Molecular Formula	C31H49N2OP
Molecular Weight	496.71 g/mol
Synonyms	Amidole-Phos; 2-(Dicyclohexylphosphino)-N,N-diisopropyl-1H-indole-1-carboxamide; N,N-Diisopropyl-2-(dicyclohexylphosphino)-1H-indole-1-carboxamide; 2-(Dicyclohexylphosphanyl)-N,N-di(propan-2-yl)-1H-indole-1-carboxamide; CAS 1067175-36-3; Phosphine Ligand Amidole-Phos; Dicyclohexyl(1-(diisopropylcarbamoyl)-1H-indol-2-yl)phosphine
EINECS	Contact for details

Quality Control

Every batch of 2-(Dicyclohexylphosphino)-N,n-Bis(1-Methylethyl)-1H-Indole-1-Carboxamide undergoes rigorous analytical testing to ensure a minimum purity of 98% and compliance with stringent internal specifications. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substance profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 98.0%
Purity (NMR)	Conforms
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.