Description

42-o-[2-[[Hydroxy[2-(Trimethylammonio)Ethoxy]Phosphinyl]Oxy]Ethyl] Rapamycin Inner Salt is a chemically modified derivative of the potent immunosuppressant and mTOR inhibitor, rapamycin (sirolimus). This compound is engineered to enhance solubility and bioavailability, making it a critical intermediate for advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector focused on developing next-generation therapeutics, particularly in oncology, immunology, and anti-aging research.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel rapamycin analogs and prodrugs for enhanced drug delivery.
• Biomedical Research: Used as a tool compound in preclinical studies to investigate mTOR pathway inhibition, cellular senescence, and autophagy.
• Drug Discovery: Essential for structure-activity relationship (SAR) studies aimed at developing targeted therapies with improved pharmacokinetic profiles.
• Immunosuppressant Development: A precursor for creating new-generation immunosuppressive agents with potential applications in organ transplantation and autoimmune diseases.
• Oncology Research: Investigated for the development of targeted cancer therapeutics that leverage mTOR inhibition to halt tumor growth.
• Coatings for Medical Devices: Potential use in creating drug-eluting coatings for stents or implants to prevent restenosis or rejection.

Basic Information

Product Name	42-o-[2-[[Hydroxy[2-(Trimethylammonio)Ethoxy]Phosphinyl]Oxy]Ethyl] Rapamycin Inner Salt
CAS No.	1062645-51-5
Molecular Formula	C56H91N2O16P
Molecular Weight	1079.31 g/mol
Synonyms	Rapamycin 42-O-[2-((2-(Trimethylammonio)ethoxy)(hydroxy)phosphoryl)ethyl] Inner Salt; Phosphorylethyl Rapamycin Quaternary Ammonium Salt; 42-O-(2-((2-(Trimethylammonio)ethoxy)(hydroxy)phosphoryl)ethyl)sirolimus; mTOR Inhibitor Derivative; Rapamycin Phosphonate Ester; Sirolimus 42-O-(2-phosphonooxyethyl) derivative; Temsirolimus related compound
EINECS	Contact for details

Quality Control

Our 42-o-[2-[[Hydroxy[2-(Trimethylammonio)Ethoxy]Phosphinyl]Oxy]Ethyl] Rapamycin Inner Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.