Description

9R-Cobicistat is a high-purity, non-competitive pharmaceutical intermediate and active pharmaceutical ingredient (API) primarily used as a pharmacokinetic enhancer. Its core value lies in its ability to inhibit cytochrome P450 3A enzymes, thereby boosting the bioavailability and efficacy of co-administered antiretroviral drugs. This compound is essential for manufacturers in the global pharmaceutical industry developing and producing advanced HIV treatment regimens, as well as for research institutions conducting pharmacological studies.

Application

• Pharmaceutical Ingredient: Critical component in fixed-dose combination antiretroviral therapies (ART) for HIV-1 infection.
• Pharmacokinetic Booster: Used to enhance the systemic exposure and prolong the half-life of protease inhibitors like atazanavir and darunavir.
• API Intermediate: Serves as a key building block in the synthesis of finished dosage forms (tablets).
• Research & Development: Utilized in preclinical and clinical studies for developing new HIV treatment protocols and drug interaction studies.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC, LC-MS, and NMR method development and validation.

Basic Information

Product Name	9R-Cobicistat
CAS No.	1051463-82-1
Molecular Formula	C₄₀H₅₃N₇O₅S₂
Molecular Weight	776.02 g/mol
Synonyms	Cobicistat; GS-9350; 9R-Cobicistat; 1,3-Thiazol-5-ylmethyl N-[(1R)-1-[(2R,5R)-5-[[(2-methylpropan-2-yl)oxycarbonyl]amino]-1,6-diphenylhexan-2-yl]carbamoyl]-2-phenylethyl]carbamate; (R)-1,3-Thiazol-5-ylmethyl (2R,5R)-5-[(N-{(2R)-1-[(1,3-thiazol-5-ylmethoxy)carbonyl]-2-phenylethyl}carbamoyl)amino]-1,6-diphenylhexan-2-ylcarbamate; Tybost (brand name component); Pharmacokinetic Enhancer
EINECS	Contact for details

Quality Control

Our 9R-Cobicistat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided, detailing results for identity, purity, and specified impurities via methods such as HPLC, NMR, and LC-MS. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.