Description

Hydroxy Cobicistat CAS NO 1051463-40-1 is a key pharmaceutical intermediate and a structural analog of the pharmacokinetic enhancer cobicistat. This compound is of significant value in the research and development of antiviral therapies, particularly for HIV treatment regimens. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the synthesis of novel drug candidates and the optimization of drug delivery systems.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of cobicistat and related pharmacokinetic enhancers for antiviral medications.
• Antiviral Drug Research: Used in R&D for developing and optimizing HIV protease inhibitor-based combination therapies to improve bioavailability and efficacy.
• Metabolism Studies: Employed in preclinical and clinical research to study cytochrome P450 enzyme inhibition and drug-drug interaction profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical production.
• Process Chemistry: Utilized in scale-up and process optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: A valuable compound for universities and research institutes studying medicinal chemistry and pharmacodynamics.

Basic Information

Product Name	Hydroxy Cobicistat
CAS No.	1051463-40-1
Molecular Formula	C40H53N7O5S2
Molecular Weight	776.02 g/mol
Synonyms	1,3-Thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino]-4-(morpholin-4-yl)butan-2-yl]carbamoyl}amino]-4-phenylbutan-2-yl]carbamate; GS-9350 Hydroxy Analog; Cobicistat Hydroxy Analog; GS-9350 Impurity; (2R,5R)-5-((S)-2-(N-(Isobutylthiazol-4-ylmethyl)-N-methylcarbamoylamino)-4-morpholinobutanamido)-1,6-diphenyl-2-(thiazol-5-ylmethoxycarbonylamino)hexan-3-yl acetate; Hydroxycobicistat
EINECS	Contact for details

Quality Control

Our Hydroxy Cobicistat is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.