Description

Gsk1349572 CAS NO 1051375-16-6 is a high-purity, small molecule compound belonging to the class of integrase strand transfer inhibitors (INSTIs). This compound is of significant interest for its potent and selective activity, making it a critical intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in antiviral drug discovery, particularly for HIV treatment. Our supply ensures consistent quality and reliable availability for critical R&D and manufacturing processes.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for quality control and method validation in the production of antiviral APIs.
• Biochemical Research: Used as a potent tool compound in enzymatic assays to study integrase inhibition mechanisms and structure-activity relationships (SAR).
• Preclinical Development: Employed as a key intermediate in the synthesis and optimization of next-generation HIV integrase inhibitors.
• Antiviral Drug Discovery: Acts as a core scaffold for medicinal chemistry programs aimed at developing novel INSTIs with improved resistance profiles.
• Academic Research: Utilized in university and institutional labs for fundamental virology and pharmacology studies related to HIV replication.

Basic Information

Product Name	Gsk1349572
CAS No.	1051375-16-6
Molecular Formula	C₂₀H₁₉F₂N₃O₅
Molecular Weight	419.38 g/mol
Synonyms	Dolutegravir Intermediate; GSK1349572; (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide; BMS-707035; S/GSK1349572; INSTI Inhibitor; HIV-1 Integrase Inhibitor
EINECS	Contact for details

Quality Control

Every batch of Gsk1349572 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) that detail specifications including assay, related substances, residual solvents, and chiral purity. Our quality standards are designed to meet the rigorous demands of pharmaceutical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Chiral Purity (HPLC)	≥99.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.