Description

Cabotegravir (GSK744, GSK1265744) is a potent integrase strand transfer inhibitor (INSTI) developed for long-acting HIV prevention and treatment. This innovative compound matters for its role in advancing long-acting injectable antiretroviral therapy, offering a significant improvement in patient adherence and quality of life. It is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development of novel HIV pre-exposure prophylaxis (PrEP) and treatment regimens.

Application

• Long-Acting Injectable (LAI) HIV Prevention (PrEP): As the active pharmaceutical ingredient (API) in long-acting injectable formulations for pre-exposure prophylaxis.
• Long-Acting Injectable HIV Treatment: As a key component in combination antiretroviral therapy (cART) for the management of HIV-1 infection.
• Pharmaceutical Research & Development: For preclinical and clinical studies investigating new dosage forms and delivery mechanisms.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Formulation Development: For stability studies and the development of nano-suspensions or other advanced drug delivery systems.

Basic Information

Product Name	Cabotegravir
CAS No.	1051375-10-0
Molecular Formula	C19H17F2N3O5
Molecular Weight	405.35 g/mol
Synonyms	GSK744; GSK1265744; (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide; Cabotegravir Sodium; S/GSK1265744; Long-acting integrase inhibitor
EINECS	Contact for details

Quality Control

Our Cabotegravir is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet the highest standards for pharmaceutical intermediates and API development. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.