Description

4-Carboxy-2-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected intermediate in modern organic synthesis, particularly in cross-coupling reactions, enabling the construction of complex fluorinated aromatic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for introducing the 4-carboxy-2-fluorophenyl moiety into biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic rings for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in creating novel herbicides, fungicides, and insecticides with fluorinated aromatic components.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis or as a scaffold in material science research.
• Chemical Biology Probes: Useful for constructing fluorinated probes and tags for studying biological systems and protein interactions.
• Polymer and Material Science: Acts as a monomer or functionalization agent in the production of advanced polymers and organic electronic materials.

Basic Information

Product Name	4-Carboxy-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1050423-87-4
Molecular Formula	C14H18BFO4
Molecular Weight	280.10 g/mol
Synonyms	2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid; (2-Fluoro-4-carboxyphenyl)boronic Acid Pinacol Ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzoic Acid; 2-Fluoro-4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl))benzoic Acid; Pinacol (2-Fluoro-4-carboxyphenyl)boronate; B-(2-Fluoro-4-carboxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Carboxy-2-fluorophenylboronic Acid, Pinacol Ester
EINECS	Contact for details

Quality Control

Our 4-Carboxy-2-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and custom purity grades or analytical specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.