Description

(2S,4R)-4-(2-Fluorobenzyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a stereochemically defined pyrrolidine core with a fluorinated aromatic side chain. This compound matters as a sophisticated chiral building block, enabling the precise construction of complex molecules with defined three-dimensional architecture. It is primarily needed by pharmaceutical and biotechnology R&D teams for applications in medicinal chemistry, particularly in the development of novel therapeutics such as enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disease targets.
• Protease Inhibitor Scaffold: Used in the design and synthesis of potential inhibitors for proteolytic enzymes like DPP-4, based on its constrained pyrrolidine carboxylic acid structure.
• Peptidomimetics: Serves as a critical component for creating peptide mimics to enhance metabolic stability and bioavailability of drug candidates.
• Ligand for Asymmetric Catalysis: Can be utilized to develop novel chiral ligands or organocatalysts for asymmetric synthesis.
• Chemical Biology Probe: Employed in the synthesis of tool compounds for studying biological pathways and target engagement.
• Academic & Contract Research: Used in university and CRO settings for fundamental research in organic synthesis and medicinal chemistry.

Basic Information

Product Name	(2S,4R)-4-(2-Fluorobenzyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	1049977-87-8
Molecular Formula	C₁₂H₁₄FNO₂
Molecular Weight	223.25 g/mol
Synonyms	(2S,4R)-4-[(2-Fluorophenyl)methyl]-2-pyrrolidinecarboxylic acid; 4-(2-Fluorobenzyl)-D-proline; (2S,4R)-4-(2-Fluorobenzyl)proline; (4R)-4-[(2-Fluorophenyl)methyl]-L-proline; (2S,4R)-4-(2-Fluorobenzyl)pyrrolidine-2-carboxylic acid; 1049977-87-8; (2S,4R)-4-(2-Fluorobenzyl)-2-carboxypyrrolidine
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-(2-Fluorobenzyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.